JPET #211334 Title Page 5-hydroxytryptamine mediated neurotransmission modulates spontaneous and vagal evoked glutamate release in the nucleus tractus solitary (NTS) - effect of uptake blockade
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Title Page 5-hydroxytryptamine mediated neurotransmission modulates spontaneous and vagal evoked glutamate release in the nucleus tractus solitary (NTS)-effect of uptake blockade This article has not been copyedited and formatted. The final version may differ from this version. Abstract The effect of blockade of either 5-HT/serotonin transporter (5-HTT/SERT) with citalopram or the organic cation transporter 3 (OCT3)/plasma membrane monoamine transporter
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5-hydroxytryptamine-mediated neurotransmission modulates spontaneous and vagal-evoked glutamate release in the nucleus of the solitary tract effect of uptake blockade.
The effect of blockade of either 5-hydroxytryptamine (5-HT)/serotonin transporter (SERT) with citalopram or the organic cation transporter 3 (OCT3)/plasma membrane monoamine transporter (PMAT) with decynium-22 (D-22) on spontaneous and evoked release of 5-HT in the nucleus tractus solitarius (NTS) was investigated in rat brainstem slices treated with gabazine. 5-HT release was measured indirect...
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Acute hyperglycemia has profound effects on vagally mediated gastrointestinal functions. We have reported recently that the release of glutamate from the central terminals of vagal afferent neurons is correlated directly with the extracellular glucose concentration. The present study was designed to test the hypothesis that 5-HT(3) receptors present on vagal afferent nerve terminals are involve...
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The nucleus tractus solitarii (nTS) is the primary termination and integration point for visceral afferents in the brain stem. Afferent glutamate release and its efficacy on postsynaptic activity within this nucleus are modulated by additional neuromodulators and transmitters, including serotonin (5-HT) acting through its receptors. The 5-HT(2) receptors in the medulla modulate the cardiorespir...
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Roberts BL, Zhu M, Zhao H, Dillon C, Appleyard SM. High glucose increases action potential firing of catecholamine neurons in the nucleus of the solitary tract by increasing spontaneous glutamate inputs. Am J Physiol Regul Integr Comp Physiol 313: R229–R239, 2017. First published June 14, 2017; doi:10.1152/ajpregu.00413. 2016.—Glucose is a crucial substrate essential for cell survival and funct...
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There is evidence that sympathoexcitatory and respiratory responses to chemoreflex activation involve ventrolateral medulla-projecting nucleus tractus solitarius (NTS) neurons (NTS-VLM neurons) and also that ATP modulates this neurotransmission. Here, we evaluated whether or not astrocytes is the source of endogenous ATP modulating the synaptic transmission in NTS-VLM neurons. Synaptic activiti...
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